Assay Detail
Binding
CHEMBL691453
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]pyrilamine from human cloned histamine H1 receptor expressed in CHO cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of 2-(aminoalkyl)-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives: a novel series of 5-HT(2A/2C) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 8.24 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329566 | — | — | 1 | 9.27 |
| CHEMBL329268 | — | — | 1 | 9.20 |
| CHEMBL328573 | — | — | 1 | 9.19 |
| CHEMBL92667 | — | — | 1 | 9.15 |
| CHEMBL316068 | — | — | 1 | 8.92 |
| CHEMBL328662 | — | — | 1 | 8.72 |
| CHEMBL96429 | — | — | 1 | 8.63 |
| CHEMBL318659 | — | — | 1 | 8.52 |
| CHEMBL2112371 | — | — | 1 | 8.46 |
| CHEMBL327651 | — | — | 1 | 8.43 |
| CHEMBL92337 | — | — | 1 | 8.43 |
| CHEMBL327306 | — | — | 1 | 8.37 |
| CHEMBL328356 | — | — | 1 | 8.22 |
| CHEMBL329685 | — | — | 1 | 8.03 |
| CHEMBL93321 | — | — | 1 | 8.02 |
| CHEMBL96158 | — | — | 1 | 7.85 |
| CHEMBL328209 | — | — | 1 | 7.69 |
| CHEMBL96732 | — | — | 1 | 7.57 |
| CHEMBL96471 | — | — | 1 | 7.53 |
| CHEMBL330713 | — | — | 1 | 7.49 |
| CHEMBL314968 | — | — | 1 | 7.33 |
| CHEMBL92333 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329566 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL329268 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL328573 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL92667 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL316068 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL328662 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL96429 | — | Ki | = | 2.36 | nM | 8.63 |
| CHEMBL318659 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2112371 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL327651 | — | Ki | = | 3.74 | nM | 8.43 |
| CHEMBL92337 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL327306 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL328356 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL329685 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL93321 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL96158 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL328209 | — | Ki | = | 20.6 | nM | 7.69 |
| CHEMBL96732 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL96471 | — | Ki | = | 29.7 | nM | 7.53 |
| CHEMBL330713 | — | Ki | = | 32.6 | nM | 7.49 |
| CHEMBL314968 | — | Ki | = | 47.1 | nM | 7.33 |
| CHEMBL92333 | — | Ki | = | 471.0 | nM | 6.33 |