Assay Detail
Functional
CHEMBL691455
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-erbB-2 overexpressing HB4a cell proliferation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.82 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281006 | — | — | 1 | 7.01 |
| CHEMBL416031 | — | — | 1 | 6.54 |
| CHEMBL31108 | — | — | 1 | 6.46 |
| CHEMBL31407 | — | — | 1 | 5.96 |
| CHEMBL32464 | — | — | 1 | 5.89 |
| CHEMBL287591 | — | — | 1 | 5.89 |
| CHEMBL31653 | — | — | 1 | 5.73 |
| CHEMBL31161 | — | — | 1 | 5.51 |
| CHEMBL281881 | — | — | 1 | 4.68 |
| CHEMBL31615 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281006 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL416031 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL31108 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL31407 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL32464 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL287591 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL31653 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL31161 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL281881 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL31615 | — | IC50 | = | 27000.0 | nM | 4.57 |