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Assay Detail

CHEMBL691473

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Functional
Ability to reduce the viral DNA in HBV infected primary duck hepatocytes to 50%
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepatitis B virus
Cell Type Hepatocyte
Confidence 1 — Organism
Curated By Intermediate

Target

Hepatitis B virus (CHEMBL613497)
Type ORGANISM
Organism Hepatitis B virus

Publication

Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.
Kumar R, Rai D, Sharma SK, Saffran HA, Blush R, Tyrrell DL.
J Med Chem (2001) 44 : 3531 -3538
PubMed 11585457 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 5.17 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL116819 1 7.40
CHEMBL3142425 1 5.18
CHEMBL3142421 1 4.93
CHEMBL3142423 1 4.82
CHEMBL3142955 1 4.70
CHEMBL3142954 1 4.63
CHEMBL318153 EDOXUDINE 2.0 1 4.54
CHEMBL3142952 1 -
CHEMBL3142947 1 -
CHEMBL610413 1 -
CHEMBL3142949 1 -
CHEMBL3142951 1 -
CHEMBL611888 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL116819 EC50 = 40.0 nM 7.40
CHEMBL3142425 EC50 = 6600.0 nM 5.18
CHEMBL3142421 EC50 = 11800.0 nM 4.93
CHEMBL3142423 EC50 = 15000.0 nM 4.82
CHEMBL3142955 EC50 = 19900.0 nM 4.70
CHEMBL3142954 EC50 = 23600.0 nM 4.63
CHEMBL318153 EDOXUDINE EC50 = 29200.0 nM 4.54
CHEMBL3142952 EC50 > 25000.0 nM -
CHEMBL3142947 EC50 > 30000.0 nM -
CHEMBL610413 EC50 > 25000.0 nM -
CHEMBL3142949 EC50 > 30000.0 nM -
CHEMBL3142951 EC50 > 30000.0 nM -
CHEMBL611888 EC50 > 25000.0 nM -