Assay Detail
Functional
CHEMBL691475
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Concentration required to inhibit 50% of cytoplasmic HBV-DNA synthesis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-Amino-6-arylthio-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) esters as novel HBV-specific antiviral reagents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.75 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106502 | ALAMIFOVIR | 2.0 | 1 | 7.52 |
| CHEMBL104475 | — | — | 1 | 7.40 |
| CHEMBL106477 | — | — | 1 | 7.30 |
| CHEMBL106367 | — | — | 1 | 7.22 |
| CHEMBL107299 | — | — | 1 | 7.22 |
| CHEMBL110868 | — | — | 1 | 7.16 |
| CHEMBL322486 | — | — | 1 | 7.10 |
| CHEMBL105973 | — | — | 1 | 7.10 |
| CHEMBL106152 | — | — | 1 | 7.05 |
| CHEMBL104516 | — | — | 1 | 7.05 |
| CHEMBL318394 | — | — | 1 | 6.92 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 6.70 |
| CHEMBL322331 | — | — | 1 | 6.54 |
| CHEMBL107249 | — | — | 1 | 6.40 |
| CHEMBL107215 | — | — | 1 | 6.28 |
| CHEMBL107674 | — | — | 1 | 6.19 |
| CHEMBL320177 | — | — | 1 | 6.08 |
| CHEMBL104711 | — | — | 1 | 6.06 |
| CHEMBL107842 | — | — | 1 | 6.01 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 5.66 |
| CHEMBL107730 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106502 | ALAMIFOVIR | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL104475 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL106477 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL106367 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL107299 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL110868 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL322486 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL105973 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL106152 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL104516 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL318394 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL484 | ADEFOVIR | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL322331 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL107249 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL107215 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL107674 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL320177 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL104711 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL107842 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL141 | LAMIVUDINE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL107730 | — | IC50 | > | 1000.0 | nM | - |