Assay Detail
Binding
CHEMBL691505
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Tested for Histone deacetylase enzyme inhibition assay using Eimeria tenella extract
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Eimeria tenella |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.20 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430060 | APICIDIN | — | 1 | 9.00 |
| CHEMBL1793973 | — | — | 1 | 8.42 |
| CHEMBL1791134 | — | — | 1 | 8.05 |
| CHEMBL1793972 | — | — | 1 | 7.96 |
| CHEMBL1791140 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430060 | APICIDIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1793973 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1791134 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1793972 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1791140 | — | IC50 | = | 28.0 | nM | 7.55 |