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Assay Detail

CHEMBL691509

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Binding
Inhibitory concentration determined against Histone deacetylase from Eimeria tenella
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Eimeria tenella
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Histone deacetylase (CHEMBL3626)
Type SINGLE PROTEIN
Organism Cryptosporidium parvum

Publication

Histone deacetylase inhibitors.
Miller TA, Witter DJ, Belvedere S.
J Med Chem (2003) 46 : 5097 -5116
PubMed 14613312 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 8.57 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2371000 1 9.10
CHEMBL430060 APICIDIN 1 9.00
CHEMBL2371006 1 9.00
CHEMBL2371007 1 8.40
CHEMBL2370998 1 8.40
CHEMBL2370999 1 7.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2371000 IC50 = 0.8 nM 9.10
CHEMBL430060 APICIDIN IC50 = 1.0 nM 9.00
CHEMBL2371006 IC50 = 1.0 nM 9.00
CHEMBL2371007 IC50 = 4.0 nM 8.40
CHEMBL2370998 IC50 = 4.0 nM 8.40
CHEMBL2370999 IC50 = 30.0 nM 7.52