Assay Detail
Binding
CHEMBL691615
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Binding affinity towards human histamine H1 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective optimization of side activities: another way for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.82 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.68 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.59 |
| CHEMBL285802 | ZOTEPINE | 2.0 | 1 | 8.47 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.46 |
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | 8.28 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 7.72 |
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 6.24 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL85 | RISPERIDONE | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL285802 | ZOTEPINE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL715 | OLANZAPINE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL708 | ZIPRASIDONE | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL716 | QUETIAPINE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL12713 | SERTINDOLE | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 730.0 | nM | 6.14 |