Assay Detail
Binding
CHEMBL691634
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Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.23 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366965 | — | — | 1 | 9.89 |
| CHEMBL65612 | — | — | 1 | 9.32 |
| CHEMBL293652 | — | — | 1 | 8.38 |
| CHEMBL65822 | — | — | 1 | 8.38 |
| CHEMBL304185 | — | — | 1 | 8.34 |
| CHEMBL304223 | — | — | 1 | 8.30 |
| CHEMBL65699 | — | — | 1 | 8.28 |
| CHEMBL304042 | — | — | 1 | 8.20 |
| CHEMBL65492 | — | — | 1 | 8.12 |
| CHEMBL63596 | — | — | 1 | 8.00 |
| CHEMBL63424 | — | — | 1 | 7.92 |
| CHEMBL538750 | — | — | 1 | 7.85 |
| CHEMBL1719 | OLOPATADINE HYDROCHLORIDE | 4.0 | 1 | 7.80 |
| CHEMBL64067 | — | — | 1 | 7.70 |
| CHEMBL302215 | — | — | 1 | 7.62 |
| CHEMBL264979 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366965 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL65612 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL293652 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL65822 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL304185 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL304223 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL65699 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL304042 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL65492 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL63596 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL63424 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL538750 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL1719 | OLOPATADINE HYDROCHLORIDE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL64067 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL302215 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL264979 | — | Ki | = | 29.0 | nM | 7.54 |