Assay Detail
Binding
CHEMBL691797
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In vitro inhibitory activity was measured against rat liver HMG-CoA reductase
24
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.21 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323373 | — | — | 2 | 7.72 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 7.57 |
| CHEMBL320666 | — | — | 1 | 7.54 |
| CHEMBL11804 | — | — | 2 | 7.37 |
| CHEMBL103192 | — | — | 1 | 7.36 |
| CHEMBL103547 | — | — | 1 | 6.80 |
| CHEMBL318754 | — | — | 1 | 6.72 |
| CHEMBL318102 | — | — | 1 | 6.64 |
| CHEMBL419542 | — | — | 1 | 6.48 |
| CHEMBL328846 | — | — | 1 | 6.24 |
| CHEMBL103661 | — | — | 1 | 5.96 |
| CHEMBL441642 | — | — | 1 | 5.89 |
| CHEMBL323075 | — | — | 1 | 5.85 |
| CHEMBL100188 | — | — | 1 | 5.80 |
| CHEMBL2304072 | — | — | 1 | 5.24 |
| CHEMBL322399 | — | — | 1 | 5.10 |
| CHEMBL318256 | — | — | 1 | 5.10 |
| CHEMBL319739 | — | — | 1 | 4.85 |
| CHEMBL102468 | — | — | 1 | 4.52 |
| CHEMBL2303674 | — | — | 1 | - |
| CHEMBL321715 | — | — | 1 | - |
| CHEMBL102484 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323373 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL320666 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL11804 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL103192 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL103547 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL318754 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL318102 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL419542 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL328846 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL103661 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL441642 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL323075 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL100188 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL323373 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2304072 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL322399 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL318256 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL319739 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL102468 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2303674 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL11804 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL321715 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL102484 | — | IC50 | = | 200000.0 | nM | - |