Assay Detail
Functional
CHEMBL691803
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Compound was tested for visual cytotoxicity on human foreskin fibroblasts (HFF) cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of fluorosugar analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole as antivirals with potentially increased glycosidic bond stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.38 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | — | 1 | 4.62 |
| CHEMBL2367679 | — | — | 1 | 4.50 |
| CHEMBL311377 | — | — | 1 | 4.40 |
| CHEMBL2367680 | — | — | 1 | 4.00 |
| CHEMBL2367681 | — | — | 1 | - |
| CHEMBL2367676 | — | — | 1 | - |
| CHEMBL513232 | — | — | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL2367678 | — | — | 1 | - |
| CHEMBL473894 | — | — | 1 | - |
| CHEMBL2367682 | — | — | 1 | - |
| CHEMBL2367677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2367679 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL311377 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2367680 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2367681 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2367676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL513232 | — | IC50 | = | 238000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | IC50 | > | 100000.0 | nM | - |
| CHEMBL2367678 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL473894 | — | IC50 | = | 118000.0 | nM | - |
| CHEMBL2367682 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2367677 | — | IC50 | > | 100000.0 | nM | - |