Assay Detail
Functional
CHEMBL691874
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human endothelial cell growth stimulate by vascular endothelial growth factor
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Endothelial cell |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor (CHEMBL2095227) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.25 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2448066 | — | — | 1 | 8.52 |
| CHEMBL2448067 | — | — | 1 | 8.10 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 7.60 |
| CHEMBL1202478 | — | — | 1 | 7.52 |
| CHEMBL1202473 | — | — | 1 | 7.52 |
| CHEMBL1202477 | — | — | 1 | 7.52 |
| CHEMBL1744349 | — | — | 1 | 7.40 |
| CHEMBL286160 | — | — | 1 | 7.40 |
| CHEMBL1907944 | — | — | 1 | 7.40 |
| CHEMBL26641 | — | — | 1 | 7.40 |
| CHEMBL24137 | — | — | 1 | 7.30 |
| CHEMBL2448065 | — | — | 1 | 7.30 |
| CHEMBL281872 | ZD-4190 FREE BASE | 1.0 | 1 | 7.30 |
| CHEMBL1744347 | — | — | 1 | 7.30 |
| CHEMBL1907764 | — | — | 1 | 7.22 |
| CHEMBL533849 | — | — | 1 | 7.22 |
| CHEMBL422758 | — | — | 1 | 7.22 |
| CHEMBL2448064 | — | — | 1 | 7.22 |
| CHEMBL24979 | — | — | 1 | 7.22 |
| CHEMBL281990 | — | — | 1 | 7.19 |
| CHEMBL25425 | — | — | 1 | 7.16 |
| CHEMBL279459 | — | — | 1 | 7.16 |
| CHEMBL1907763 | — | — | 1 | 7.10 |
| CHEMBL283088 | — | — | 1 | 7.00 |
| CHEMBL416191 | — | — | 1 | 7.00 |
| CHEMBL25450 | — | — | 1 | 7.00 |
| CHEMBL25579 | — | — | 1 | 6.70 |
| CHEMBL428534 | — | — | 1 | 6.60 |
| CHEMBL25610 | — | — | 1 | 6.52 |
| CHEMBL24026 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2448066 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2448067 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1202478 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1202473 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1202477 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1744349 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL286160 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1907944 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL26641 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL24137 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2448065 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL281872 | ZD-4190 FREE BASE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1744347 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1907764 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL533849 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL422758 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2448064 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL24979 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL281990 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL25425 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL279459 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1907763 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL283088 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL416191 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL25450 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL25579 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL428534 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL25610 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL24026 | — | IC50 | = | 500.0 | nM | 6.30 |