Assay Detail
Functional
CHEMBL691905
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Tested for cytotoxicity against Colon carcinoma type HT-29 cell line expressing MDR-1 (-) gene
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, hydrolytic activation and cytotoxicity of etoposide prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.35 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3215425 | — | — | 1 | 8.46 |
| CHEMBL3215424 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3215425 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3215424 | — | IC50 | = | 5.7 | nM | 8.24 |