Assay Detail
Binding
CHEMBL691936
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Inhibition of solubilized partially purified rat liver HMG-CoA reductase
39
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted [1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.11 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368970 | — | — | 3 | 8.30 |
| CHEMBL2368973 | — | — | 1 | 8.22 |
| CHEMBL440891 | — | — | 3 | 8.15 |
| CHEMBL2368988 | — | — | 1 | 8.10 |
| CHEMBL2368968 | — | — | 1 | 8.00 |
| CHEMBL2368985 | — | — | 1 | 7.89 |
| CHEMBL2368984 | — | — | 1 | 7.89 |
| CHEMBL2368971 | — | — | 1 | 7.89 |
| CHEMBL2368974 | — | — | 1 | 7.89 |
| CHEMBL2368982 | — | — | 1 | 7.82 |
| CHEMBL2368964 | — | — | 1 | 7.80 |
| CHEMBL50566 | — | — | 1 | 7.66 |
| CHEMBL2368986 | — | — | 1 | 7.60 |
| CHEMBL2368962 | — | — | 1 | 7.54 |
| CHEMBL2368979 | — | — | 1 | 7.52 |
| CHEMBL2368980 | — | — | 1 | 7.44 |
| CHEMBL2368990 | — | — | 1 | 7.44 |
| CHEMBL2368989 | — | — | 1 | 7.43 |
| CHEMBL2368966 | — | — | 1 | 7.36 |
| CHEMBL2368976 | — | — | 1 | 7.31 |
| CHEMBL2368965 | — | — | 1 | 7.30 |
| CHEMBL2368978 | — | — | 1 | 7.16 |
| CHEMBL2368975 | — | — | 1 | 7.10 |
| CHEMBL54240 | — | — | 1 | 7.00 |
| CHEMBL2368983 | — | — | 1 | 6.97 |
| CHEMBL2368963 | — | — | 1 | 6.72 |
| CHEMBL2368969 | — | — | 1 | 6.43 |
| CHEMBL2368967 | — | — | 1 | 6.37 |
| CHEMBL2368972 | — | — | 1 | 6.33 |
| CHEMBL300495 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368970 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2368973 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL440891 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL440891 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL2368988 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2368968 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2368974 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2368984 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2368985 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2368971 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2368982 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2368964 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL50566 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2368970 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2368986 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2368962 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2368979 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2368990 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2368980 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2368989 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2368966 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2368976 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2368965 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2368978 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2368975 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL54240 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2368983 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL2368963 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2368970 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2368969 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2368967 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2368972 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL300495 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL2368981 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2368977 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL2368911 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL440891 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2368928 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL50348 | — | IC50 | = | 44000.0 | nM | 4.36 |