Assay Detail
Binding
CHEMBL691941
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested in vitro for its ability to inhibit rat liver HMG-CoA reductase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 5. 6-(Fluoren-9-yl)- and 6-(fluoren-9-ylidenyl)-3,5-dihydroxyhexanoic acids and their lactone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.67 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368982 | — | — | 1 | 7.82 |
| CHEMBL2368970 | — | — | 1 | 7.62 |
| CHEMBL2368975 | — | — | 1 | 7.10 |
| CHEMBL424546 | — | — | 1 | 7.07 |
| CHEMBL2368316 | — | — | 1 | 6.12 |
| CHEMBL2368319 | — | — | 1 | 6.08 |
| CHEMBL2367922 | — | — | 1 | 6.05 |
| CHEMBL2368911 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368982 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2368970 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2368975 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL424546 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2368316 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2368319 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2367922 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2368911 | — | IC50 | = | 3000.0 | nM | 5.52 |