Assay Detail
Binding
CHEMBL691943
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Inhibition of HMG-CoA reductase from rat liver
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3-Alkyl-3-hydroxyglutaric acids: a new class of hypocholesterolemic HMG CoA reductase inhibitors. 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.43 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54440 | MEVASTATIN | 2.0 | 1 | 6.00 |
| CHEMBL156576 | — | — | 1 | 4.30 |
| CHEMBL155789 | — | — | 1 | 4.30 |
| CHEMBL156577 | — | — | 1 | 4.00 |
| CHEMBL154728 | — | — | 1 | 4.00 |
| CHEMBL155977 | — | — | 1 | 4.00 |
| CHEMBL154775 | — | — | 1 | - |
| CHEMBL158184 | — | — | 1 | - |
| CHEMBL157896 | — | — | 1 | - |
| CHEMBL157719 | — | — | 1 | - |
| CHEMBL155612 | — | — | 1 | - |
| CHEMBL155172 | — | — | 1 | - |
| CHEMBL156008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54440 | MEVASTATIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL156576 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL155789 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL156577 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL154728 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL155977 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL154775 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL158184 | — | IC50 | = | 350000.0 | nM | - |
| CHEMBL157896 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL157719 | — | IC50 | = | 900000.0 | nM | - |
| CHEMBL155612 | — | IC50 | = | 750000.0 | nM | - |
| CHEMBL155172 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL156008 | — | IC50 | > | 1000000.0 | nM | - |