Assay Detail
Binding
CHEMBL691945
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In vitro inhibition of HMG-CoA reductase in solubilized rat liver.
45
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.02 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100165 | — | — | 1 | 8.57 |
| CHEMBL177545 | — | — | 1 | 8.40 |
| CHEMBL102168 | — | — | 1 | 8.22 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 8.10 |
| CHEMBL321076 | — | — | 1 | 8.00 |
| CHEMBL329307 | — | — | 1 | 7.77 |
| CHEMBL321768 | — | — | 1 | 7.70 |
| CHEMBL101633 | — | — | 1 | 7.57 |
| CHEMBL101831 | — | — | 1 | 7.52 |
| CHEMBL316712 | — | — | 1 | 7.30 |
| CHEMBL101497 | — | — | 1 | 7.30 |
| CHEMBL100721 | — | — | 2 | 7.30 |
| CHEMBL323344 | — | — | 2 | 7.22 |
| CHEMBL420646 | — | — | 1 | 7.16 |
| CHEMBL100357 | — | — | 1 | 7.16 |
| CHEMBL101662 | — | — | 1 | 7.12 |
| CHEMBL319983 | — | — | 1 | 7.10 |
| CHEMBL321713 | — | — | 1 | 7.07 |
| CHEMBL100694 | — | — | 1 | 7.05 |
| CHEMBL101512 | — | — | 1 | 7.02 |
| CHEMBL443275 | — | — | 1 | 7.02 |
| CHEMBL99834 | — | — | 1 | 7.00 |
| CHEMBL316938 | — | — | 1 | 7.00 |
| CHEMBL101774 | — | — | 1 | 6.85 |
| CHEMBL317576 | — | — | 1 | 6.82 |
| CHEMBL100560 | — | — | 1 | 6.80 |
| CHEMBL101806 | — | — | 1 | 6.72 |
| CHEMBL101718 | — | — | 1 | 6.72 |
| CHEMBL316899 | — | — | 1 | 6.60 |
| CHEMBL330662 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100165 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL177545 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL102168 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL321076 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL329307 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL321768 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL101633 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL101831 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL316712 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL101497 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL100721 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL323344 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL420646 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL100357 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL101662 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL319983 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL321713 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL100694 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL101512 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL443275 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL316938 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL99834 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL101774 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL317576 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL100560 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL101806 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL101718 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL316899 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL330662 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL103712 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL101600 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL317142 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL99838 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL317777 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL101600 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL323344 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL102199 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL100721 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL103139 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL101097 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL101824 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL100884 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL102112 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL317726 | — | IC50 | > | 1000.0 | nM | - |