Assay Detail
Binding
CHEMBL691946
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In vitro inhibition of HMG-CoA reductase of rat liver
17
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.68 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436037 | — | — | 2 | 8.60 |
| CHEMBL162125 | — | — | 1 | 8.52 |
| CHEMBL350103 | — | — | 1 | 8.22 |
| CHEMBL2110171 | — | — | 1 | 8.22 |
| CHEMBL162642 | — | — | 1 | 8.15 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 8.10 |
| CHEMBL348798 | — | — | 2 | 8.05 |
| CHEMBL159951 | — | — | 1 | 8.05 |
| CHEMBL2375156 | — | — | 1 | 7.19 |
| CHEMBL2375155 | — | — | 1 | 7.16 |
| CHEMBL161829 | — | — | 1 | 7.16 |
| CHEMBL163277 | — | — | 1 | 7.00 |
| CHEMBL160102 | — | — | 1 | 6.93 |
| CHEMBL159103 | — | — | 1 | 6.60 |
| CHEMBL345375 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436037 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL162125 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL436037 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL350103 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2110171 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL162642 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL159951 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL348798 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL348798 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2375156 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2375155 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL161829 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL163277 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL160102 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL159103 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL345375 | — | IC50 | = | 330.0 | nM | 6.48 |