Assay Detail
Binding
CHEMBL691947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat liver microsomal HMG-CoA reductase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.28 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445123 | — | — | 1 | 9.52 |
| CHEMBL119609 | — | — | 1 | 9.30 |
| CHEMBL121451 | — | — | 1 | 8.70 |
| CHEMBL120922 | — | — | 1 | 8.70 |
| CHEMBL333642 | — | — | 1 | 8.70 |
| CHEMBL331680 | — | — | 1 | 8.70 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 8.52 |
| CHEMBL333904 | — | — | 1 | 8.30 |
| CHEMBL690 | PRAVASTATIN SODIUM | 4.0 | 1 | 8.30 |
| CHEMBL332735 | — | — | 1 | 7.60 |
| CHEMBL332205 | — | — | 1 | 7.16 |
| CHEMBL420893 | — | — | 1 | 7.15 |
| CHEMBL121541 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445123 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL119609 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL121451 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL120922 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL333642 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL331680 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL333904 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL690 | PRAVASTATIN SODIUM | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL332735 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL332205 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL420893 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL121541 | — | IC50 | = | 105.0 | nM | 6.98 |