Assay Detail
Binding
CHEMBL691950
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against HMG CoA reductase
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.35 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54440 | MEVASTATIN | 2.0 | 1 | 8.00 |
| CHEMBL2367922 | — | — | 1 | 6.05 |
| CHEMBL118591 | — | — | 1 | 5.80 |
| CHEMBL118592 | — | — | 1 | 5.72 |
| CHEMBL2368928 | — | — | 2 | 4.97 |
| CHEMBL120354 | — | — | 1 | 4.82 |
| CHEMBL2367920 | — | — | 1 | 4.70 |
| CHEMBL332558 | — | — | 1 | 4.70 |
| CHEMBL120524 | — | — | 1 | 4.05 |
| CHEMBL118866 | — | — | 1 | - |
| CHEMBL120403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54440 | MEVASTATIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2367922 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL118591 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL118592 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2368928 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL120354 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL2367920 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL332558 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL2368928 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL120524 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL118866 | — | IC50 | = | 129000.0 | nM | - |
| CHEMBL120403 | — | IC50 | = | 107000.0 | nM | - |