Assay Detail
Functional
CHEMBL692128
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Cytotoxic activity against HepG2 liver cancer cell line
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro cytotoxicity of 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.96 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16678 | — | — | 1 | 7.36 |
| CHEMBL16928 | — | — | 1 | 6.55 |
| CHEMBL17429 | — | — | 1 | 6.46 |
| CHEMBL17364 | — | — | 1 | 6.45 |
| CHEMBL16532 | — | — | 1 | 6.42 |
| CHEMBL278064 | — | — | 1 | 6.41 |
| CHEMBL17137 | — | — | 1 | 6.38 |
| CHEMBL17289 | CHS-828 | 1.0 | 1 | 5.91 |
| CHEMBL17376 | — | — | 1 | 5.56 |
| CHEMBL17077 | — | — | 1 | 5.55 |
| CHEMBL417088 | — | — | 1 | 5.46 |
| CHEMBL278676 | — | — | 1 | 5.40 |
| CHEMBL17029 | — | — | 1 | 5.39 |
| CHEMBL280435 | — | — | 1 | 5.38 |
| CHEMBL417264 | — | — | 1 | 5.37 |
| CHEMBL17007 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16678 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL16928 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL17429 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL17364 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL16532 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL278064 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL17137 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL17289 | CHS-828 | IC50 | = | 1245.0 | nM | 5.91 |
| CHEMBL17376 | — | IC50 | = | 2736.0 | nM | 5.56 |
| CHEMBL17077 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL417088 | — | IC50 | = | 3446.0 | nM | 5.46 |
| CHEMBL278676 | — | IC50 | = | 4001.0 | nM | 5.40 |
| CHEMBL17029 | — | IC50 | = | 4088.0 | nM | 5.39 |
| CHEMBL280435 | — | IC50 | = | 4204.0 | nM | 5.38 |
| CHEMBL417264 | — | IC50 | = | 4317.0 | nM | 5.37 |
| CHEMBL17007 | — | IC50 | = | 4352.0 | nM | 5.36 |