Assay Detail
Functional
CHEMBL692146
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Inhibition of hDJ2 protein farnesylation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.21 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318626 | — | — | 1 | 9.05 |
| CHEMBL450336 | — | — | 1 | 8.82 |
| CHEMBL294888 | — | — | 1 | 8.68 |
| CHEMBL316673 | — | — | 1 | 8.51 |
| CHEMBL99901 | — | — | 1 | 8.40 |
| CHEMBL439047 | — | — | 1 | 8.22 |
| CHEMBL2111612 | — | — | 1 | 7.96 |
| CHEMBL322435 | — | — | 1 | 7.96 |
| CHEMBL323302 | — | — | 1 | 7.58 |
| CHEMBL400694 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318626 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL450336 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL294888 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL316673 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL99901 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL439047 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2111612 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL322435 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL323302 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL400694 | — | EC50 | = | 120.0 | nM | 6.92 |