Assay Detail
Functional
CHEMBL692152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human foreskin fibroblasts (HFF) proliferation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.40 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271136 | — | — | 1 | 6.00 |
| CHEMBL409892 | GW305178X | — | 1 | 5.72 |
| CHEMBL1964242 | — | — | 1 | 5.60 |
| CHEMBL1964245 | — | — | 1 | 5.50 |
| CHEMBL269883 | GW416981X | — | 1 | 5.44 |
| CHEMBL1964244 | — | — | 1 | 5.37 |
| CHEMBL1964250 | — | — | 1 | 5.30 |
| CHEMBL1964260 | — | — | 1 | 5.23 |
| CHEMBL411426 | — | — | 1 | 5.23 |
| CHEMBL391229 | — | — | 1 | 5.10 |
| CHEMBL1276446 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271136 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL409892 | GW305178X | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1964242 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1964245 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL269883 | GW416981X | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1964244 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1964250 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1964260 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL411426 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL391229 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL1276446 | — | IC50 | = | 13000.0 | nM | 4.89 |