Assay Detail
Functional
CHEMBL692225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in the presence of beta-Glucuronidase (betaG, 5 micro g/ml) towards human colorectal cells (HT-29)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of water-soluble glucuronide derivatives of camptothecin for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.07 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405532 | — | — | 1 | 8.18 |
| CHEMBL3215387 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405532 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3215387 | — | IC50 | = | 11.0 | nM | 7.96 |