Assay Detail
Functional
CHEMBL692229
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Cytotoxicity was determined in vitro in HT-29 cells(colon) of human tumor cell lines by using MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.71 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128315 | — | — | 1 | 8.70 |
| CHEMBL341028 | — | — | 1 | 8.22 |
| CHEMBL338843 | — | — | 1 | 7.89 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.60 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.34 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128315 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL341028 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL338843 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 331.0 | nM | 6.48 |