Assay Detail
Functional
CHEMBL692247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the incorporation of sodium [14C]acetate into cholesterol in HEP G2 cells.
22
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HepG2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.58 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102168 | — | — | 1 | 9.30 |
| CHEMBL318707 | — | — | 1 | 8.74 |
| CHEMBL177545 | — | — | 1 | 8.39 |
| CHEMBL321768 | — | — | 1 | 8.25 |
| CHEMBL100165 | — | — | 1 | 7.52 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 7.30 |
| CHEMBL329307 | — | — | 1 | 7.26 |
| CHEMBL99838 | — | — | 1 | 7.00 |
| CHEMBL101497 | — | — | 1 | 6.60 |
| CHEMBL323344 | — | — | 2 | 5.77 |
| CHEMBL321713 | — | — | 1 | 5.60 |
| CHEMBL317142 | — | — | 1 | 5.46 |
| CHEMBL101824 | — | — | 1 | 5.19 |
| CHEMBL101600 | — | — | 2 | 5.00 |
| CHEMBL102199 | — | — | 1 | 4.70 |
| CHEMBL103139 | — | — | 1 | - |
| CHEMBL101831 | — | — | 1 | - |
| CHEMBL321076 | — | — | 1 | - |
| CHEMBL102112 | — | — | 1 | - |
| CHEMBL317777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102168 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL318707 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL177545 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL321768 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL100165 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL329307 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL99838 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL101497 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL323344 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL321713 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL317142 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL101824 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL101600 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL323344 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL101600 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL102199 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL103139 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL101831 | — | IC50 | > | 1700.0 | nM | - |
| CHEMBL321076 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL102112 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL317777 | — | IC50 | > | 500.0 | nM | - |