Assay Detail
Binding
CHEMBL692283
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Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileum
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 5.38 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14587 | — | — | 1 | 6.10 |
| CHEMBL14364 | — | — | 1 | 5.60 |
| CHEMBL14484 | — | — | 1 | 5.50 |
| CHEMBL274041 | — | — | 1 | 5.40 |
| CHEMBL15153 | — | — | 1 | 5.30 |
| CHEMBL14868 | — | — | 1 | 5.10 |
| CHEMBL15056 | — | — | 1 | 5.00 |
| CHEMBL14754 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14587 | — | Kd | = | 794.33 | nM | 6.10 |
| CHEMBL14364 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL14484 | — | Kd | = | 3162.28 | nM | 5.50 |
| CHEMBL274041 | — | Kd | = | 3981.07 | nM | 5.40 |
| CHEMBL15153 | — | Kd | = | 5011.87 | nM | 5.30 |
| CHEMBL14868 | — | Kd | = | 7943.28 | nM | 5.10 |
| CHEMBL15056 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL14754 | — | Kd | = | 10000.0 | nM | 5.00 |