Assay Detail
Functional
CHEMBL692391
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Human tumor cell cytotoxicity assay was performed using MTT (HT-29 cell line )
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Water soluble inhibitors of topoisomerase I: quaternary salt derivatives of camptothecin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.31 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422886 | — | — | 1 | 7.89 |
| CHEMBL350118 | — | — | 1 | 7.80 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.60 |
| CHEMBL445914 | — | — | 1 | 7.34 |
| CHEMBL162904 | — | — | 1 | 7.16 |
| CHEMBL163006 | — | — | 1 | 7.12 |
| CHEMBL423808 | — | — | 1 | 7.08 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422886 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL350118 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL445914 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL162904 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL163006 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL423808 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 330.0 | nM | 6.48 |