Assay Detail
Functional
CHEMBL692393
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In vitro Cytotoxic activity of compound in comparison with reference compounds in human cell line HT-29
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
8,11-dihydroxy-6-[(aminoalkyl)amino]-7H-benzo[e]perimidin-7-ones with activity in multidrug-resistant cell lines: synthesis and antitumor evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.42 | 7.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.71 |
| CHEMBL418866 | — | — | 1 | 7.31 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL418866 | — | IC50 | = | 49.1 | nM | 7.31 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 56.4 | nM | 7.25 |