Assay Detail
Functional
CHEMBL692405
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In vitro cytotoxicity against HT-29 (human colon adenocarcinoma) cell line.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Chromophore-modified bis-naphthalimides: synthesis and antitumor activity of bis-dibenz[de,h]isoquinoline-1,3-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.26 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139659 | — | — | 1 | 8.70 |
| CHEMBL335633 | — | — | 1 | 8.40 |
| CHEMBL142086 | — | — | 1 | 8.05 |
| CHEMBL141972 | — | — | 1 | 8.05 |
| CHEMBL31400 | ELINAFIDE | 2.0 | 1 | 7.85 |
| CHEMBL335553 | — | — | 1 | 7.72 |
| CHEMBL336040 | — | — | 1 | 7.70 |
| CHEMBL140793 | — | — | 1 | 7.52 |
| CHEMBL140002 | — | — | 1 | 7.46 |
| CHEMBL89414 | — | — | 1 | 7.39 |
| CHEMBL342909 | — | — | 1 | 7.16 |
| CHEMBL140742 | — | — | 1 | 7.12 |
| CHEMBL141593 | — | — | 1 | 7.05 |
| CHEMBL137958 | — | — | 1 | 7.02 |
| CHEMBL140598 | — | — | 1 | 7.02 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 6.85 |
| CHEMBL265113 | — | — | 1 | 6.70 |
| CHEMBL43482 | MITONAFIDE | 2.0 | 1 | 6.22 |
| CHEMBL263668 | — | — | 1 | 5.70 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139659 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL335633 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL142086 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL141972 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL31400 | ELINAFIDE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL335553 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL336040 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL140793 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL140002 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL89414 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL342909 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL140742 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL141593 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL137958 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL140598 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL265113 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL43482 | MITONAFIDE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL263668 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 3000.0 | nM | 5.52 |