Assay Detail
Functional
CHEMBL692407
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In vitro cytotoxicity was tested against human colon adenocarcinoma HT-29 cell line
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2,3-Dihydro-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7-trione derivatives, a class of cytotoxic agents active on multidrug-resistant cell lines: synthesis, biological evaluation, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.68 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.00 |
| CHEMBL86287 | — | — | 1 | 7.66 |
| CHEMBL544311 | — | — | 1 | 7.66 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.58 |
| CHEMBL553744 | — | — | 1 | 7.26 |
| CHEMBL85471 | — | — | 1 | 7.17 |
| CHEMBL553593 | — | — | 1 | 7.16 |
| CHEMBL85039 | — | — | 1 | 7.15 |
| CHEMBL83416 | — | — | 1 | 6.68 |
| CHEMBL85377 | — | — | 1 | 6.66 |
| CHEMBL418930 | — | — | 1 | 6.52 |
| CHEMBL83620 | — | — | 1 | 6.51 |
| CHEMBL85087 | — | — | 1 | 6.43 |
| CHEMBL82722 | — | — | 1 | 6.38 |
| CHEMBL82952 | — | — | 1 | 6.05 |
| CHEMBL84219 | — | — | 1 | 6.05 |
| CHEMBL83128 | — | — | 1 | 5.47 |
| CHEMBL432951 | — | — | 1 | 5.33 |
| CHEMBL83297 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL86287 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL544311 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL553744 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL85471 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL553593 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL85039 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL83416 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL85377 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL418930 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL83620 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL85087 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL82722 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL82952 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL84219 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL83128 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL432951 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL83297 | — | IC50 | = | 6700.0 | nM | 5.17 |