Assay Detail
Binding
CHEMBL692514
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Inhibition of rat microsomal HMG-CoA reductase activity by 50%
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.24 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319318 | — | — | 1 | 8.92 |
| CHEMBL102145 | — | — | 1 | 8.72 |
| CHEMBL329989 | — | — | 1 | 8.68 |
| CHEMBL101621 | — | — | 1 | 8.66 |
| CHEMBL318784 | — | — | 1 | 8.55 |
| CHEMBL101826 | — | — | 1 | 8.52 |
| CHEMBL101436 | — | — | 1 | 8.42 |
| CHEMBL175236 | — | — | 1 | 8.40 |
| CHEMBL99700 | — | — | 1 | 8.22 |
| CHEMBL100820 | — | — | 1 | 8.17 |
| CHEMBL101438 | — | — | 1 | 8.07 |
| CHEMBL100947 | — | — | 1 | 7.89 |
| CHEMBL98469 | — | — | 1 | 7.82 |
| CHEMBL321279 | — | — | 1 | 7.62 |
| CHEMBL330182 | — | — | 1 | 7.58 |
| CHEMBL690 | PRAVASTATIN SODIUM | 4.0 | 1 | 7.58 |
| CHEMBL419344 | — | — | 1 | 7.16 |
| CHEMBL101764 | — | — | 1 | 7.06 |
| CHEMBL321712 | — | — | 1 | 6.92 |
| CHEMBL101721 | — | — | 1 | 6.79 |
| CHEMBL319834 | — | — | 1 | 6.53 |
| CHEMBL101668 | — | — | 1 | 5.52 |
| CHEMBL99954 | — | — | 1 | 5.35 |
| CHEMBL101493 | — | — | 1 | 5.34 |
| CHEMBL100742 | — | — | 1 | 4.67 |
| CHEMBL100807 | — | — | 1 | 4.15 |
| CHEMBL99898 | — | — | 1 | 4.05 |
| CHEMBL100504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319318 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL102145 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL329989 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL101621 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL318784 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL101826 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL101436 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL175236 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL99700 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL100820 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL101438 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL100947 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL98469 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL321279 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL330182 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL690 | PRAVASTATIN SODIUM | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL419344 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL101764 | — | IC50 | = | 87.5 | nM | 7.06 |
| CHEMBL321712 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL101721 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL319834 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL101668 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL99954 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL101493 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL100742 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL100807 | — | IC50 | = | 70500.0 | nM | 4.15 |
| CHEMBL99898 | — | IC50 | = | 89300.0 | nM | 4.05 |
| CHEMBL100504 | — | IC50 | = | 150000.0 | nM | - |