Assay Detail
Functional
CHEMBL692518
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for inhibition of rat hepatic HMG-CoA reductase.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.06 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97121 | — | — | 1 | 8.92 |
| CHEMBL94800 | — | — | 1 | 8.89 |
| CHEMBL329478 | — | — | 1 | 8.85 |
| CHEMBL96953 | — | — | 1 | 8.60 |
| CHEMBL418776 | — | — | 1 | 8.40 |
| CHEMBL94584 | — | — | 1 | 8.29 |
| CHEMBL94994 | — | — | 1 | 7.90 |
| CHEMBL92891 | — | — | 1 | 7.71 |
| CHEMBL690 | PRAVASTATIN SODIUM | 4.0 | 1 | 7.62 |
| CHEMBL94575 | — | — | 1 | 7.54 |
| CHEMBL314756 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97121 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL94800 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL329478 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL96953 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL418776 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL94584 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL94994 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL92891 | — | IC50 | = | 19.4 | nM | 7.71 |
| CHEMBL690 | PRAVASTATIN SODIUM | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL94575 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL314756 | — | IC50 | = | 1300.0 | nM | 5.89 |