Assay Detail
Binding
CHEMBL692524
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of HMG-CoA reductase (COR) in rats.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.10 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54440 | MEVASTATIN | 2.0 | 1 | 7.60 |
| CHEMBL333258 | — | — | 1 | 7.60 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 7.55 |
| CHEMBL333933 | — | — | 1 | 7.50 |
| CHEMBL122112 | — | — | 1 | 7.28 |
| CHEMBL122937 | — | — | 1 | 7.10 |
| CHEMBL123082 | — | — | 1 | 6.70 |
| CHEMBL122947 | — | — | 1 | 6.46 |
| CHEMBL334113 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54440 | MEVASTATIN | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL333258 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL333933 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL122112 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL122937 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL123082 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL122947 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL334113 | — | IC50 | = | 720.0 | nM | 6.14 |