Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL692692

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against histone deacetylase enzyme derived from partially purified extracts of Eimeria tenella protozoa using [3H]11 as radioligand
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cryptosporidium parvum
Confidence 9 — Direct single protein target
Curated By Expert

Target

Histone deacetylase (CHEMBL3626)
Type SINGLE PROTEIN
Organism Cryptosporidium parvum

Publication

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.
Colletti SL, Myers RW, Darkin-Rattray SJ, Gurnett AM, Dulski PM, Galuska S, Allocco JJ, Ayer MB, Li C, Lim J, Crumley TM, Cannova C, Schmatz DM, Wyvratt MJ, Fisher MH, Meinke PT.
Bioorg Med Chem Lett (2001) 11 : 113 -117
PubMed 11206439 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 7.86 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1793985 1 9.70
CHEMBL1793982 1 9.10
CHEMBL1793989 1 9.00
CHEMBL430060 APICIDIN 1 9.00
CHEMBL1793983 1 8.70
CHEMBL1793974 1 8.52
CHEMBL1793990 1 8.40
CHEMBL1793973 1 8.40
CHEMBL1793994 1 8.30
CHEMBL1793967 1 8.00
CHEMBL1793972 1 7.96
CHEMBL1793969 1 7.70
CHEMBL1793980 1 7.64
CHEMBL1793976 1 7.60
CHEMBL1793979 1 7.52
CHEMBL1793968 1 7.48
CHEMBL1793981 1 7.35
CHEMBL1793978 1 7.30
CHEMBL1793977 1 7.00
CHEMBL1793993 1 7.00
CHEMBL1793988 1 6.76
CHEMBL1793975 1 6.70
CHEMBL1793986 1 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1793985 IC50 = 0.2 nM 9.70
CHEMBL1793982 IC50 = 0.8 nM 9.10
CHEMBL1793989 IC50 = 1.0 nM 9.00
CHEMBL430060 APICIDIN IC50 = 1.0 nM 9.00
CHEMBL1793983 IC50 = 2.0 nM 8.70
CHEMBL1793974 IC50 = 3.0 nM 8.52
CHEMBL1793990 IC50 = 4.0 nM 8.40
CHEMBL1793973 IC50 = 4.0 nM 8.40
CHEMBL1793994 IC50 = 5.0 nM 8.30
CHEMBL1793967 IC50 = 10.0 nM 8.00
CHEMBL1793972 IC50 = 11.0 nM 7.96
CHEMBL1793969 IC50 = 20.0 nM 7.70
CHEMBL1793980 IC50 = 23.0 nM 7.64
CHEMBL1793976 IC50 = 25.0 nM 7.60
CHEMBL1793979 IC50 = 30.0 nM 7.52
CHEMBL1793968 IC50 = 33.0 nM 7.48
CHEMBL1793981 IC50 = 45.0 nM 7.35
CHEMBL1793978 IC50 = 50.0 nM 7.30
CHEMBL1793977 IC50 = 100.0 nM 7.00
CHEMBL1793993 IC50 = 100.0 nM 7.00
CHEMBL1793988 IC50 = 175.0 nM 6.76
CHEMBL1793975 IC50 = 200.0 nM 6.70
CHEMBL1793986 IC50 = 2500.0 nM 5.60