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Assay Detail

CHEMBL692694

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Eimeria tenella
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Histone deacetylase (CHEMBL4740)
Type SINGLE PROTEIN
Organism Cryptosporidium parvum

Publication

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.
Colletti SL, Myers RW, Darkin-Rattray SJ, Gurnett AM, Dulski PM, Galuska S, Allocco JJ, Ayer MB, Li C, Lim J, Crumley TM, Cannova C, Schmatz DM, Wyvratt MJ, Fisher MH, Meinke PT.
Bioorg Med Chem Lett (2001) 11 : 113 -117
PubMed 11206439 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 7.25 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL430060 APICIDIN 1 8.10
CHEMBL1793971 1 8.00
CHEMBL1793982 1 7.70
CHEMBL1793973 1 7.52
CHEMBL1793983 1 7.30
CHEMBL1793972 1 7.16
CHEMBL1793981 1 7.00
CHEMBL1793969 1 6.70
CHEMBL1793970 1 6.60
CHEMBL1793978 1 6.40
CHEMBL1793987 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL430060 APICIDIN Ki = 8.0 nM 8.10
CHEMBL1793971 Ki = 10.0 nM 8.00
CHEMBL1793982 Ki = 20.0 nM 7.70
CHEMBL1793973 Ki = 30.0 nM 7.52
CHEMBL1793983 Ki = 50.0 nM 7.30
CHEMBL1793972 Ki = 70.0 nM 7.16
CHEMBL1793981 Ki = 100.0 nM 7.00
CHEMBL1793969 Ki = 200.0 nM 6.70
CHEMBL1793970 Ki = 250.0 nM 6.60
CHEMBL1793978 Ki = 400.0 nM 6.40
CHEMBL1793987 Ki > 1000.0 nM -