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Assay Detail

CHEMBL692697

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards histone deacetylase (HDAC) enzyme derived from chicken liver (CL) cells using [3H]11
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Gallus gallus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.
Colletti SL, Myers RW, Darkin-Rattray SJ, Gurnett AM, Dulski PM, Galuska S, Allocco JJ, Ayer MB, Li C, Lim J, Crumley TM, Cannova C, Schmatz DM, Wyvratt MJ, Fisher MH, Meinke PT.
Bioorg Med Chem Lett (2001) 11 : 113 -117
PubMed 11206439 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 7.59 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1793975 1 8.52
CHEMBL1793976 1 8.30
CHEMBL1793994 1 8.30
CHEMBL1793993 1 8.00
CHEMBL1793967 1 7.92
CHEMBL1793979 1 7.70
CHEMBL1793980 1 7.52
CHEMBL1793988 1 7.22
CHEMBL1793977 1 7.10
CHEMBL1793986 1 5.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1793975 Ki = 3.0 nM 8.52
CHEMBL1793976 Ki = 5.0 nM 8.30
CHEMBL1793994 Ki = 5.0 nM 8.30
CHEMBL1793993 Ki = 10.0 nM 8.00
CHEMBL1793967 Ki = 12.0 nM 7.92
CHEMBL1793979 Ki = 20.0 nM 7.70
CHEMBL1793980 Ki = 30.0 nM 7.52
CHEMBL1793988 Ki = 60.0 nM 7.22
CHEMBL1793977 Ki = 80.0 nM 7.10
CHEMBL1793986 Ki = 4500.0 nM 5.35