Assay Detail
Functional
CHEMBL692723
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HepG2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of dihydroeptastatin, a novel inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.88 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487720 | — | — | 1 | 7.92 |
| CHEMBL175236 | — | — | 1 | 7.54 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 7.43 |
| CHEMBL115307 | — | — | 1 | 5.85 |
| CHEMBL323880 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487720 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL175236 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL115307 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL323880 | — | IC50 | = | 2220.0 | nM | 5.65 |