Assay Detail
Binding
CHEMBL692754
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Inhibitory activity against HIV-1 reverse transcriptase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and HIV-1 reverse transcriptase inhibition properties of two new methylenephosphonate analogues of 3-azido-3-deoxythymidine-5-triphosphate
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.37 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 7.37 |
| CHEMBL1160470 | — | — | 1 | 4.41 |
| CHEMBL1160479 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1160470 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL1160479 | — | IC50 | = | 48000.0 | nM | 4.32 |