Assay Detail
Functional
CHEMBL692783
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In vitro inhibition of Bax regulated release of cytochrome C was determined using liposome channel assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.28 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139312 | — | — | 1 | 7.54 |
| CHEMBL344483 | — | — | 1 | 6.43 |
| CHEMBL334802 | — | — | 1 | 6.33 |
| CHEMBL136513 | — | — | 1 | 6.32 |
| CHEMBL343732 | — | — | 1 | 6.28 |
| CHEMBL136947 | — | — | 1 | 6.17 |
| CHEMBL136744 | — | — | 1 | 6.17 |
| CHEMBL336890 | — | — | 1 | 6.02 |
| CHEMBL344194 | — | — | 1 | 5.90 |
| CHEMBL136725 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139312 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL344483 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL334802 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL136513 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL343732 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL136947 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL136744 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL336890 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL344194 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL136725 | — | IC50 | = | 2380.0 | nM | 5.62 |