Assay Detail
Functional
CHEMBL692795
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Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HES |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of dihydroeptastatin, a novel inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.83 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487720 | — | — | 1 | 8.19 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 7.89 |
| CHEMBL175236 | — | — | 1 | 7.77 |
| CHEMBL115307 | — | — | 1 | 5.16 |
| CHEMBL323880 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487720 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL175236 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL115307 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL323880 | — | IC50 | = | 7280.0 | nM | 5.14 |