Assay Detail

CHEMBL692887

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Functional

Compound was evaluated for antiproliferative activity against human colon adenocarcinoma (HT-29) cell lines.

ChEMBL ↗

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Target

HT-29 (CHEMBL384) ↗

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Primary target HT-29

CHEMBL384

Anchored from Assay target.

Protein identity HT-29

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HT-29
Confidence	1 — Organism
Curated By	Intermediate

Target

HT-29 (CHEMBL384) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and antiproliferative activity of a cyclic analog of dolastatin 10.

Poncet J, Hortala L, Busquet M, Guéritte-Voegelein F, Thoret S, Pierré A, Atassi G, Jouin P.
Bioorg Med Chem Lett (1998) 8 : 2855 -2858
PubMed 9873636 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.73	10.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL39541	DOLASTATIN-10	2.0	1	10.22
CHEMBL318667	—	—	1	7.23

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL39541	DOLASTATIN-10	IC50	=	0.06	nM	10.22
CHEMBL318667	—	IC50	=	58.5	nM	7.23