Assay Detail
Binding
CHEMBL692983
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Inhibitory activity against human Histamine H1 receptor
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.02 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | 7.90 |
| CHEMBL1241 | TRIPELENNAMINE | 4.0 | 1 | 7.40 |
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 6.80 |
| CHEMBL158352 | — | — | 1 | 6.60 |
| CHEMBL157217 | — | — | 1 | 6.40 |
| CHEMBL157273 | — | — | 1 | 6.40 |
| CHEMBL94249 | — | — | 1 | 6.30 |
| CHEMBL152126 | — | — | 1 | 6.20 |
| CHEMBL275507 | — | — | 1 | 6.10 |
| CHEMBL24665 | — | — | 1 | 6.00 |
| CHEMBL155188 | — | — | 1 | 6.00 |
| CHEMBL152122 | — | — | 1 | 5.90 |
| CHEMBL156071 | — | — | 1 | 5.90 |
| CHEMBL32813 | — | — | 1 | 5.90 |
| CHEMBL345185 | — | — | 1 | 5.70 |
| CHEMBL287052 | — | — | 1 | 5.70 |
| CHEMBL155314 | — | — | 1 | 5.70 |
| CHEMBL359122 | — | — | 1 | 5.60 |
| CHEMBL157842 | — | — | 1 | 5.60 |
| CHEMBL90063 | — | — | 1 | 5.50 |
| CHEMBL152221 | — | — | 1 | 5.40 |
| CHEMBL154566 | — | — | 1 | 5.10 |
| CHEMBL154068 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511 | PYRILAMINE | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL1241 | TRIPELENNAMINE | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL90 | HISTAMINE | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL158352 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL157217 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL157273 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL94249 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL152126 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL275507 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL24665 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL155188 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL152122 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL156071 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL32813 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL345185 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL287052 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL155314 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL359122 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL157842 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL90063 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL152221 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL154566 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL154068 | — | IC50 | = | 50118.72 | nM | 4.30 |