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Assay Detail

CHEMBL692986

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Binding
Binding affinity of human cortical histamine H1 receptor
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Histamine H1 receptor (CHEMBL231)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.
Faghih R, Dwight W, Vasudevan A, Dinges J, Conner SE, Esbenshade TA, Bennani YL, Hancock AA.
Bioorg Med Chem Lett (2002) 12 : 3077 -3079
PubMed 12372505 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 5.97 7.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL105669 1 7.56
CHEMBL320178 1 6.80
CHEMBL317900 1 6.74
CHEMBL322873 1 6.56
CHEMBL105483 1 6.45
CHEMBL323562 1 6.37
CHEMBL446885 1 6.36
CHEMBL106602 1 6.35
CHEMBL101692 1 6.30
CHEMBL105762 1 6.25
CHEMBL102416 1 6.24
CHEMBL105567 1 6.12
CHEMBL104947 1 5.83
CHEMBL319000 1 5.72
CHEMBL421026 1 5.54
CHEMBL106483 1 5.49
CHEMBL102984 1 5.46
CHEMBL419912 1 5.43
CHEMBL106545 1 5.43
CHEMBL2112461 1 5.41
CHEMBL105967 1 5.41
CHEMBL105515 1 5.40
CHEMBL106596 1 5.11
CHEMBL105594 1 5.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL105669 Ki = 27.54 nM 7.56
CHEMBL320178 Ki = 158.49 nM 6.80
CHEMBL317900 Ki = 181.97 nM 6.74
CHEMBL322873 Ki = 275.42 nM 6.56
CHEMBL105483 Ki = 354.81 nM 6.45
CHEMBL323562 Ki = 426.58 nM 6.37
CHEMBL446885 Ki = 436.52 nM 6.36
CHEMBL106602 Ki = 446.68 nM 6.35
CHEMBL101692 Ki = 501.19 nM 6.30
CHEMBL105762 Ki = 562.34 nM 6.25
CHEMBL102416 Ki = 575.44 nM 6.24
CHEMBL105567 Ki = 758.58 nM 6.12
CHEMBL104947 Ki = 1479.11 nM 5.83
CHEMBL319000 Ki = 1905.46 nM 5.72
CHEMBL421026 Ki = 2884.03 nM 5.54
CHEMBL106483 Ki = 3235.94 nM 5.49
CHEMBL102984 Ki = 3467.37 nM 5.46
CHEMBL419912 Ki = 3715.35 nM 5.43
CHEMBL106545 Ki = 3715.35 nM 5.43
CHEMBL2112461 Ki = 3890.45 nM 5.41
CHEMBL105967 Ki = 3890.45 nM 5.41
CHEMBL105515 Ki = 3981.07 nM 5.40
CHEMBL106596 Ki = 7762.47 nM 5.11
CHEMBL105594 Ki = 8912.51 nM 5.05