Assay Detail
Binding
CHEMBL693166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against histone deacetylase (HDAC1 and HDAC2) isolated from K562 erythroleukemia cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Histone deacetylase (HDAC1 and HDAC2) (CHEMBL2111429) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.64 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123626 | — | — | 1 | 8.68 |
| CHEMBL124282 | — | — | 1 | 8.60 |
| CHEMBL339720 | — | — | 1 | 8.57 |
| CHEMBL340885 | — | — | 1 | 8.37 |
| CHEMBL435415 | — | — | 1 | 8.37 |
| CHEMBL123905 | — | — | 1 | 8.36 |
| CHEMBL125042 | — | — | 1 | 8.24 |
| CHEMBL124650 | — | — | 1 | 8.17 |
| CHEMBL340835 | — | — | 1 | 8.07 |
| CHEMBL127846 | — | — | 1 | 8.01 |
| CHEMBL340113 | — | — | 1 | 7.96 |
| CHEMBL126274 | — | — | 1 | 7.96 |
| CHEMBL339796 | — | — | 1 | 7.92 |
| CHEMBL127184 | — | — | 1 | 7.89 |
| CHEMBL124909 | — | — | 1 | 7.72 |
| CHEMBL339534 | — | — | 1 | 7.68 |
| CHEMBL338776 | — | — | 1 | 7.64 |
| CHEMBL127269 | — | — | 1 | 7.52 |
| CHEMBL126273 | — | — | 1 | 7.38 |
| CHEMBL127360 | — | — | 1 | 7.33 |
| CHEMBL125098 | — | — | 1 | 7.24 |
| CHEMBL123506 | — | — | 1 | 7.13 |
| CHEMBL124593 | — | — | 1 | 7.05 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.85 |
| CHEMBL124322 | — | — | 1 | 6.48 |
| CHEMBL112211 | — | — | 1 | 6.47 |
| CHEMBL123624 | — | — | 1 | 6.25 |
| CHEMBL57107 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123626 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL124282 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL339720 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL340885 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL435415 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL123905 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL125042 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL124650 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL340835 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL127846 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL340113 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL126274 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL339796 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL127184 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL124909 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL339534 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL338776 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL127269 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL126273 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL127360 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL125098 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL123506 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL124593 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL124322 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL112211 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL123624 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL57107 | — | IC50 | = | 1010.0 | nM | 6.00 |