Assay Detail
Binding
CHEMBL693167
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Inhibitory activity against mixture of histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2) from nuclear extraction of K562 erythroleukemia cells.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Histone deacetylase (HDAC1 and HDAC2) (CHEMBL2111429) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Alpha-keto amides as inhibitors of histone deacetylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 8.05 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114184 | — | — | 1 | 10.70 |
| CHEMBL432618 | — | — | 1 | 10.21 |
| CHEMBL321689 | — | — | 1 | 10.09 |
| CHEMBL432243 | — | — | 1 | 9.96 |
| CHEMBL113303 | — | — | 1 | 9.96 |
| CHEMBL112984 | — | — | 1 | 8.85 |
| CHEMBL113033 | — | — | 1 | 8.51 |
| CHEMBL112446 | — | — | 1 | 8.43 |
| CHEMBL115049 | — | — | 1 | 8.43 |
| CHEMBL113034 | — | — | 1 | 8.37 |
| CHEMBL321253 | — | — | 1 | 8.31 |
| CHEMBL324429 | — | — | 1 | 8.04 |
| CHEMBL420300 | — | — | 1 | 8.03 |
| CHEMBL111898 | — | — | 1 | 8.02 |
| CHEMBL333150 | — | — | 1 | 7.96 |
| CHEMBL113094 | — | — | 1 | 7.75 |
| CHEMBL320921 | — | — | 1 | 7.68 |
| CHEMBL112340 | — | — | 1 | 6.88 |
| CHEMBL112742 | — | — | 1 | 6.84 |
| CHEMBL444534 | — | — | 1 | 6.70 |
| CHEMBL113093 | — | — | 1 | 6.62 |
| CHEMBL112211 | — | — | 1 | 6.47 |
| CHEMBL113156 | — | — | 1 | 6.28 |
| CHEMBL112171 | — | — | 1 | 6.07 |
| CHEMBL322710 | — | — | 1 | 5.98 |
| CHEMBL326842 | — | — | 1 | - |
| CHEMBL325736 | — | — | 1 | - |
| CHEMBL113566 | — | — | 1 | - |
| CHEMBL113495 | — | — | 1 | - |
| CHEMBL265564 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114184 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL432618 | — | IC50 | = | 0.062 | nM | 10.21 |
| CHEMBL321689 | — | IC50 | = | 0.082 | nM | 10.09 |
| CHEMBL432243 | — | IC50 | = | 0.109 | nM | 9.96 |
| CHEMBL113303 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL112984 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL113033 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL112446 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL115049 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL113034 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL321253 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL324429 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL420300 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL111898 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL333150 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL113094 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL320921 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL112340 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL112742 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL444534 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL113093 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL112211 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL113156 | — | IC50 | = | 526.0 | nM | 6.28 |
| CHEMBL112171 | — | IC50 | = | 853.0 | nM | 6.07 |
| CHEMBL322710 | — | IC50 | = | 1041.0 | nM | 5.98 |
| CHEMBL326842 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL325736 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL113566 | — | IC50 | > | 5.0 | nM | - |
| CHEMBL113495 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL265564 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL113367 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL112148 | — | IC50 | = | 2.9 | nM | - |