Assay Detail
Binding
CHEMBL693168
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Inhibitory activity was tested against histone deacetylase (HDAC).
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Histone deacetylase (HDAC1 and HDAC2) (CHEMBL2111429) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Indole amide hydroxamic acids as potent inhibitors of histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.56 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294194 | — | — | 1 | 8.51 |
| CHEMBL57792 | — | — | 1 | 8.51 |
| CHEMBL54409 | — | — | 1 | 8.46 |
| CHEMBL301223 | — | — | 1 | 8.46 |
| CHEMBL58487 | — | — | 1 | 8.27 |
| CHEMBL294447 | — | — | 1 | 8.20 |
| CHEMBL293812 | — | — | 1 | 8.19 |
| CHEMBL56214 | — | — | 1 | 8.00 |
| CHEMBL54408 | — | — | 1 | 7.93 |
| CHEMBL56782 | — | — | 1 | 7.92 |
| CHEMBL57106 | — | — | 1 | 7.90 |
| CHEMBL57226 | — | — | 1 | 7.90 |
| CHEMBL55719 | — | — | 1 | 7.87 |
| CHEMBL56157 | — | — | 1 | 7.84 |
| CHEMBL56344 | — | — | 1 | 7.82 |
| CHEMBL59316 | — | — | 1 | 7.82 |
| CHEMBL54172 | — | — | 1 | 7.80 |
| CHEMBL59317 | — | — | 1 | 7.77 |
| CHEMBL57033 | — | — | 1 | 7.77 |
| CHEMBL56699 | — | — | 1 | 7.72 |
| CHEMBL56012 | — | — | 1 | 7.53 |
| CHEMBL55499 | — | — | 1 | 7.50 |
| CHEMBL57032 | — | — | 1 | 7.44 |
| CHEMBL294464 | — | — | 1 | 7.43 |
| CHEMBL52518 | — | — | 1 | 7.42 |
| CHEMBL55864 | — | — | 1 | 7.40 |
| CHEMBL55728 | — | — | 1 | 7.39 |
| CHEMBL53363 | — | — | 1 | 7.33 |
| CHEMBL54867 | — | — | 1 | 7.25 |
| CHEMBL55611 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294194 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL57792 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL54409 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL301223 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL58487 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL294447 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL293812 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL56214 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL54408 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL56782 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL57106 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL57226 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL55719 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL56157 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL59316 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL56344 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL54172 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL57033 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL59317 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL56699 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL56012 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL55499 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL57032 | — | IC50 | = | 36.4 | nM | 7.44 |
| CHEMBL294464 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL52518 | — | IC50 | = | 37.6 | nM | 7.42 |
| CHEMBL55864 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL55728 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL53363 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL54867 | — | IC50 | = | 56.5 | nM | 7.25 |
| CHEMBL55611 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL54543 | — | IC50 | = | 80.3 | nM | 7.09 |
| CHEMBL53455 | — | IC50 | = | 87.6 | nM | 7.06 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL55234 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL56770 | — | IC50 | = | 732.0 | nM | 6.13 |
| CHEMBL57107 | — | IC50 | = | 1006.0 | nM | 6.00 |
| CHEMBL56040 | — | IC50 | = | 1680.0 | nM | 5.78 |