Assay Detail
Functional
CHEMBL693199
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Ability of compound to inhibit [3H]MTX influx in Hela cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.21 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10804 | — | — | 1 | 6.13 |
| CHEMBL10591 | — | — | 1 | 5.57 |
| CHEMBL11133 | ISOAMINOPTERIN | — | 1 | 5.05 |
| CHEMBL11187 | — | — | 1 | 4.68 |
| CHEMBL10592 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10804 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL10591 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL11133 | ISOAMINOPTERIN | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL11187 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL10592 | — | IC50 | = | 25000.0 | nM | 4.60 |