Assay Detail
Binding
CHEMBL693299
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Observed binding affinity against Human leukocyte elastase (HLE)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of human leukocyte elastase. 3.1 inhibition by tetrahydrobenzisothiazolinylmethyl aryl carboxylates
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.12 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314218 | — | — | 1 | 10.52 |
| CHEMBL432049 | — | — | 1 | 10.15 |
| CHEMBL326848 | — | — | 1 | 9.15 |
| CHEMBL112119 | — | — | 1 | 9.00 |
| CHEMBL326136 | — | — | 1 | 9.00 |
| CHEMBL90327 | — | — | 1 | 8.70 |
| CHEMBL274085 | — | — | 1 | 8.70 |
| CHEMBL113688 | — | — | 1 | 7.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314218 | — | Ki | = | 0.0302 | nM | 10.52 |
| CHEMBL432049 | — | Ki | = | 0.07079 | nM | 10.15 |
| CHEMBL326848 | — | Ki | = | 0.7079 | nM | 9.15 |
| CHEMBL112119 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL326136 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL90327 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL274085 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL113688 | — | Ki | = | 18.2 | nM | 7.74 |