Assay Detail
Functional
CHEMBL693433
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Effective concentration for transcriptional activation of aromatase in Human cell native protein assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cell line |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.89 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 7.35 |
| CHEMBL298687 | — | — | 1 | 7.23 |
| CHEMBL266282 | AL-43 | — | 1 | 6.80 |
| CHEMBL46325 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131 | PREDNISOLONE | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL298687 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL266282 | AL-43 | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL46325 | — | EC50 | = | 640.0 | nM | 6.19 |