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Assay Detail

CHEMBL693504

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The compound was tested for binding affinity against yeast Heat shock protein HSP 90
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Heat shock protein HSP 90-alpha (CHEMBL3880)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH.
J Med Chem (1999) 42 : 260 -266
PubMed 9925731 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 7.72 7.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL414883 RADICICOL 1 7.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL414883 RADICICOL Kd = 19.0 nM 7.72